• 98% Purity Buy Acadesine Bulk SARM Powder AICAR Raw Source
  • 98% Purity Buy Acadesine Bulk SARM Powder AICAR Raw Source
  • 98% Purity Buy Acadesine Bulk SARM Powder AICAR Raw Source
  • 98% Purity Buy Acadesine Bulk SARM Powder AICAR Raw Source
  • 98% Purity Buy Acadesine Bulk SARM Powder AICAR Raw Source
  • 98% Purity Buy Acadesine Bulk SARM Powder AICAR Raw Source

98% Purity Buy Acadesine Bulk SARM Powder AICAR Raw Source

50.0 USD
Min. Order:
10 Gram
Trade Term:
FOB,CFR,CIF
Payment Terms:
Wester Union,Money Gram,Bank Transfer,T/T
Place of Origin:
Shanghai, China (Mainland)
Means of Transport:
Land, Ocean, Air
Production Capacity:
50kg/month
Packing:
Discreet Package
Delivery Date:
Within 24 hours
Brand Name:
Yijing
CAS No.:
2627-69-2
Purity:
99%
Alias:
YK11
Molecular formula:
C21H18F3NO3S2
Molecular weight:
453.50
Grade:
Pharmaceutical Grade
Appearance:
White Powder
Storage:
Shading, confined preservation
Shipment:
EMS, DHL, FedEx, TNT
Certification:
GMP, HSE, ISO 9001, USP, BP
Leading Time:
About 5~8 working days
Product Description

Skype: histeroids

Whatsapp:+86 18121080540


Acadesine/AICAR Powder CAS:2627-69-2

Alias:AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE

CAS:2627-69-2

EINECS:220-097-5

Molecular Formula:C9H14N4O5

Molecular Weight:258.23

Apperance: White or off-white powder.


Acadesine/AICAR Powder Description:

AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide.It can also be known as AICA ribonucleotide, ZMP, or Acadesine.It is an intermediate contained in the generation of inosine monophosphate.It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.


AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.


With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion.Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.


Acadesine/AICAR Powder Biological Activity:

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.


Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.


Acadesine/AICAR Powder Functions:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.


Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).


The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.


AICAR Quality Test Report(COA):

Item

Specification

Result

Appearance

White powder

Complies

Related substance (HPLC)

Total impurity ≤0.5%
Max single impurity ≤0.1%

0.2%
0.06%

Odor

Characteristic

Complies

Assay

99%

99.8%

Sieve analysis

100% pass 80 mesh

Complies

Loss on Drying
Residue on Ignition

≤1.0%
≤1.0%

0.12%
0.09%

Heavy Metal

<10ppm

Complies

As

<0.1ppm

0.05ppm

Pb

<0.1ppm

0.05ppm

Cd

<0.1ppm

0.05ppm

Residual Solvents

<100ppm

Complies

Residual Pesticide

Negative

Complies

Microbiology



Total Plate Count

<1000cfu/g

Complies

Yeast & Mold

<100cfu/g

Complies

E.Coli

Negative

Complies

Salmonella

Negative

Complies







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